Alcoholism leads to Nutrient Depletion Deficiencies of vitamin B1, B2, B3, B5, B6, B12, folic acid, and biotin have all been found to cause depression, and alcohol depletes all of these vitamins. Alpert, J. and Fava, M. (1997) found 15 to 38 percent of depressed patients were deficient in folic acid. Alcohol depletes all of the B vitamins, Vitamin A, Vitamin C, Vitamin D, and Vitamin E, calcium, magnesium, zinc, potassium and selenium.